Zifi 200

Zifi 200 is an antibiotic medicine commonly used to treat bacterial infections. It contains Cefixime as its active ingredient, which is a third-generation cephalosporin antibiotic.

Composition:

Cefixime (200 mg): Active ingredient

Excipients: May include binders, fillers, and stabilizers depending on the manufactures

Mode of Action of Zifi 20

Cefixime works by interfering with bacterial cell wall synthesis. Here's how it acts in detail:

Targeting Bacterial Cell Wall:

Bacteria have a protective outer cell wall made up of peptidoglycan, a complex mesh of sugar and amino acid chains.

Cefixime binds to specific proteins in the bacterial cell wall known as penicillin-binding proteins (PBPs).

Inhibiting Peptidoglycan Cross-Linking:

PBPs play a key role in the final stages of peptidoglycan synthesis by cross-linking peptidoglycan chains to strengthen the cell wall.

Cefixime inhibits PBPs, thereby preventing this cross-linking.

Disruption of Cell Wall Integrity:

Without proper cross-linking, the bacterial cell wall becomes weak and unable to withstand internal osmotic pressure.

Bacterial Cell Lysis and Death:

As a result, the bacterial cell undergoes lysis (bursting) and dies, effectively clearing the infection.

Spectrum of Activity Of Zifi 20

Cefixime is broad-spectrum, effective against many Gram-negative bacteria (e.g., E. coli, Klebsiella, H. influenzae) and some Gram-positive bacteria (e.g., Streptococcus pneumoniae).

It is less effective against Gram-positive organisms compared to earlier-generation cephalosporins.

Pharmacokinetics:

Absorption: Cefixime is well-absorbed after oral administration, with moderate bioavailability (~50%).

Distribution: It distributes widely in the body and achieves effective concentrations at infection sites.

Excretion: Primarily excreted unchanged in the urine, making it effective for urinary tract infections.

Uses (Indications) of Zifi 200

Zifi 200 (Cefixime) is a broad-spectrum third-generation cephalosporin antibiotic. It is used for treating various bacterial infections caused by susceptible organisms. Below is a detailed list of its indications:

1. Respiratory Tract Infections (Upper and Lower)

Pathogens: Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis

Acute Bronchitis: Helps in resolving inflammation caused by bacterial pathogens.

Chronic Bronchitis (acute exacerbations): Reduces bacterial burden during flare-ups.

Pharyngitis and Tonsillitis: Treats infections caused by Streptococcus pyogenes (alternative to penicillin in penicillin-allergic patients).

Sinusitis: Useful for treating sinus infections with purulent discharge.

2. Urinary Tract Infections (UTIs)

Pathogens: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae

Effective for acute uncomplicated UTIs (e.g., cystitis in women).

Also used in complicated UTIs, though additional drugs may be required for severe infections.

3. Otitis Media (Middle Ear Infections)

Pathogens: Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae

Commonly used for acute otitis media in children and adults.

Reduces ear pain, fever, and infection duration.

4. Sexually Transmitted Infections (STIs)

Pathogen: Neisseria gonorrhoeae

Used for uncomplicated gonorrhea, especially in cases where fluoroquinolones or penicillin cannot be used.

5. Typhoid Fever

Pathogen: Salmonella typhi

Cefixime is effective in treating typhoid fever, particularly drug-resistant strains.

Often preferred due to its oral formulation and efficacy against S. typhi.

6. Skin and Soft Tissue Infections

Pathogens: Staphylococcus aureus (excluding MRSA), Streptococcus pyogenes

Treats mild to moderate infections such as cellulitis, impetigo, and infected wounds.

7. Bone and Joint Infections

Sometimes used for infections like osteomyelitis, though not the first-line choice

8. Bacterial Gastrointestinal Infections

Pathogen: Shigella spp., Salmonella spp.

Treats infections causing gastroenteritis, including dysentery.

9. Pelvic Inflammatory Disease (PID)

May be part of combination therapy for mild PID caused by susceptible organisms.

10. Other Infections

Prostatitis: Caused by Gram-negative bacteria.

Septicemia: As an adjunct in early-stage infections caused by sensitive organisms.

When is Zifi 200 Prescribed?

It is prescribed when:

The infection is caused by bacteria sensitive to Cefixime.

Alternative antibiotics (like penicillin) are unsuitable due to resistance or allergy.

The patient prefers oral therapy instead of injections.

Cautions in Prescribing:

Avoid in viral infections (e.g., common cold, flu).

Not effective against methicillin-resistant Staphylococcus aureus (MRSA).

May require combination therapy for severe infections.

Dosage of Zifi 200

The dosage of Zifi 200 (Cefixime) depends on the patient's age, weight, severity of the infection, and the type of bacterial infection being treated. Below are detailed dosage recommendations:

1. Adults and Adolescents (≥12 years or ≥50 kg body weight)

General Dosage:

200 mg twice daily or 400 mg once daily.

Taken with or without food.

Duration:

Usually 5–14 days depending on the infection type and severity.

Infection-Specific Dosage:

Uncomplicated Urinary Tract Infections (UTIs): 200 mg twice daily for 5–7 days.

Respiratory Tract Infections (e.g., bronchitis, pneumonia): 200 mg twice daily for 7–14 days.

Gonorrhea (Uncomplicated): A single dose of 400 mg is sufficient.

Typhoid Fever: 200 mg twice daily for 10–14 days.

2. Pediatric Patients (<12 years or <50 kg body weight)

Weight-Based Dosage:

8 mg/kg/day, administered either

As a single daily dose, or

Divided into two doses (4 mg/kg every 12 hours).

Examples:

For a child weighing 20 kg:

Total daily dose = 8 × 20 = 160 mg.

Administer 80 mg twice daily or 160 mg once daily.

Duration:

Otitis Media: 10 days.

Pharyngitis/Tonsillitis: 10–14 days.

UTIs/Respiratory Infections: 7–10 days.

3. Elderly Patients

Dosage is the same as for adults but requires caution if renal function is impaired.

4. Patients with Renal Impairment

Adjusted Dosage:

If creatinine clearance (CrCl) <60 mL/min: Reduce the dose or extend the dosing interval.

Suggested regimen:

CrCl 21–60 mL/min: 75% of the usual dose or normal dose every 24 hours.

CrCl ≤20 mL/min: 50% of the usual dose or normal dose every 36–48 hours.

Administration Guidelines

With or Without Food: Food slightly delays absorption but does not affect efficacy.

Swallow Whole: The tablet should not be crushed or chewed.

Overdose Management

Symptoms of overdose: Nausea, vomiting, diarrhea, and abdominal pain.

Treatment: Symptomatic and supportive. Severe cases may require gastric lavage or hemodialysis (in case of renal impairment)

General Recommendations

Complete the full course of the antibiotic to prevent bacterial resistance, even if symptoms improve.

Follow the prescribed dosing schedule for best efficacy.

also read Augmentin 625 a broad spectrum antibiotic - click below

https://www.medinsighthub.com/augmentin-625mg-uses-dosage-and-side-effects

Side Effects of Zifi 200 (Cefixime)

Zifi 200 (Cefixime), like other antibiotics, can cause side effects in some individuals. These can range from mild to severe. Below is a detailed overview:

1. Common Side Effects

These are usually mild and temporary:

Gastrointestinal Issues:

Diarrhea (most common)

Nausea

Vomiting

Abdominal pain or discomfort

Skin Reactions:

Rash

Itching (pruritus)

Mild skin irritation

2. Less Common Side Effects

May occur in a smaller percentage of people:

Hypersensitivity Reactions:

Urticaria (hives)

Angioedema (swelling of lips, face, or throat)

Allergic reactions, especially in patients with a history of penicillin allergy

Central Nervous System Effects:

Headache

Dizziness

Hematological Changes:

Eosinophilia (increase in eosinophils)

Transient changes in blood counts (e.g., thrombocytopenia, leukopenia)

3. Severe Side Effects

These are rare but require immediate medical attention:

Severe Allergic Reactions (Anaphylaxis):

Difficulty breathing

Severe rash or hives

Swelling of the throat or tongue

Clostridioides difficile-Associated Diarrhea (CDAD):

Severe, persistent diarrhea with abdominal cramping

May occur due to overgrowth of C. difficile in the gut after prolonged use.

Kidney Issues:

Interstitial nephritis (inflammation of kidney tissue)

Reduced kidney function in susceptible patients

Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN):

Severe skin reactions with blistering, peeling, and widespread rashes

Hepatotoxicity (Liver Issues):

Elevated liver enzymes (ALT, AST)

Rarely, jaundice or hepatitis

4. Superinfections

Fungal Infections: Overgrowth of non-susceptible organisms like Candida, leading to oral thrush or vaginal yeast infections.

Bacterial Resistance: Long-term or inappropriate use may lead to antibiotic resistance.

5. Side Effects in Special Populations

Children: Diarrhea and skin rash are more common.

Elderly: More prone to renal impairment and associated complications.

Patients with Renal Impairment: Higher risk of toxicity if dosage adjustments are not made.

When to Contact a Doctor

Seek medical attention if you experience:

Severe allergic reactions (swelling, rash, or difficulty breathing)

Persistent diarrhea or signs of C. difficile infection

Jaundice (yellowing of skin/eyes)

Blood in stools or urine

Severe skin reactions

Management of Side Effects

Mild side effects (e.g., nausea, diarrhea) often resolve on their own. Stay hydrated.

Probiotics may help prevent antibiotic-associated diarrhea.

Discontinue and consult a doctor if severe side effects occur.

Contraindications of Zifi 200( Cefixime)

Zifi 200 contains Cefixime, a third-generation cephalosporin antibiotic. The contraindications for Zifi 200 include:

Allergy to Cefixime or Cephalosporins
Patients with a known hypersensitivity to Cefixime, cephalosporins, or any component of the formulation.

Cross-Allergy to Penicillins
Caution or avoidance in patients with a history of severe allergic reactions (e.g., anaphylaxis) to penicillins, due to potential cross-sensitivity.

Severe Renal Impairment
Adjustments may be required, but in severe cases where dose modification is not feasible, the medication may be contraindicated.

History of Antibiotic-Associated Colitis
Use is contraindicated in patients with a history of Clostridium difficile-associated diarrhea or other forms of antibiotic-associated colitis.

Porphyria
Cephalosporins may exacerbate porphyria, so their use is contraindicated in patients with a history of the condition.

Severe Hepatic Impairment
In rare cases, if liver metabolism is significantly impaired, alternative antibiotics may be preferred.

Pregnancy and Breastfeeding (Relative Contraindication)
While Cefixime is generally considered safe, it should be used during pregnancy or breastfeeding only if clearly needed and prescribed by a doctor.

Drug Interactions of Zifi 200

Zifi 200, containing Cefixime, may interact with other medications. Below are common drug interactions associated with Cefixime:

Anticoagulants (e.g., Warfarin)

Effect: Increased anticoagulant effect, leading to a higher risk of bleeding.

Mechanism: Cefixime can alter gut flora, reducing vitamin K synthesis and enhancing the anticoagulant effect.

Recommendation: Monitor INR (International Normalized Ratio) and adjust the anticoagulant dose if necessary.

Probenecid

Effect: Increased plasma levels of Cefixime.

Mechanism: Probenecid inhibits the renal excretion of Cefixime.

Recommendation: Use cautiously or consider an alternative if dose adjustments are not feasible.

Oral Contraceptives

Effect: Reduced efficacy of oral contraceptives.

Mechanism: Antibiotics may disrupt gut flora, which could impair estrogen reabsorption.

Recommendation: Advise using additional contraceptive methods during and shortly after the antibiotic course.

Live Vaccines (e.g., Typhoid Vaccine)

Effect: Reduced vaccine efficacy.

Mechanism: Antibiotics may interfere with the activity of live bacterial vaccines.

Recommendation: Avoid administering live bacterial vaccines during Cefixime treatment.

Other Nephrotoxic Drugs (e.g., Aminoglycosides, Loop Diuretics)

Effect: Increased risk of nephrotoxicity.

Mechanism: Combined effects on the kidneys when used with other nephrotoxic drugs.

Recommendation: Monitor renal function closely when these drugs are used concurrently.

Carbamazepine

Effect: Increased plasma levels of Carbamazepine.

Mechanism: Cefixime may inhibit the metabolism of Carbamazepine.

Recommendation: Monitor Carbamazepine levels and adjust the dose if needed.

Antacids or H2 Receptor Antagonists (e.g., Ranitidine)

Effect: Potential reduction in Cefixime absorption.

Mechanism: Alteration of stomach pH may reduce the bioavailability of Cefixime.

Recommendation: Administer Cefixime at least 1-2 hours before or after antacids or H2 blockers.

General Recommendations:

Always inform your healthcare provider about all medications, supplements, and herbal products being taken.

Regular monitoring may be required for medications with significant interactions.

Other Brands available for Cefixime

Here are some other brands of Cefixime 200mg available in India along with their respective companies:

Mahacef by Mankind Pharma Ltd.

Cefspan by GlaxoSmithKline Pharmaceuticals Ltd.

Taxim O by Alkem Laboratories Ltd.

Cefix by Lupin Ltd.

Omnix by Sanofi India Ltd.

Cefolac by Intra Labs India Pvt. Ltd.

Milixim by Molekule India Pvt. Ltd.

Topcef by Abbott India Ltd.

Fixicom by Indoco Remedies Ltd.

Please note that this is not an exhaustive list and there may be other brands available in the market. Additionally, it's always best to consult with a healthcare professional or pharmacist before taking any medication.

FAQ of Zifi 200 (Cefixime)

What is ZIFI 200 medicine used for?

Zifi 200 (Cefixime) is used to treat bacterial infections such as respiratory tract infections, urinary tract infections, and ear infections.

Is ZIFI a strong antibiotic?

Cefixime is a broad-spectrum antibiotic, considered effective but not the strongest.

Is Zifi 200 banned in India?

No, Zifi 200 is not banned in India.

Can we take ZIFI 200 for a cough?

Only if the cough is due to a bacterial infection as prescribed by a doctor.

Which antibiotic is best for a cough?

It depends on the cause. Amoxicillin or azithromycin are commonly used for bacterial respiratory infections.

Which is better, ZIFI or Amoxicillin?

It depends on the infection. Amoxicillin is preferred for mild infections; Zifi (Cefixime) for resistant bacteria.

Which antibiotic is best for chest infection?

Amoxicillin, Azithromycin, or Cefixime, depending on the severity and type of infection.

What is the top strongest antibiotic?

Drugs like Vancomycin or Carbapenems are considered very strong antibiotics for severe infections.

Is cefixime good for cough?

Yes, if the cough is caused by a bacterial infection like bronchitis.

Is cefixime a strong antibiotic?

It is moderately strong and effective against many resistant bacteria.

How long does it take for Zifi to work?

It usually starts showing effects within 24-48 hours.

Can I take ZIFI 200 twice a day?

Yes, it is typically taken twice daily as prescribed by a doctor.

Does Zifi cause sleep?

Drowsiness is not a common side effect, but fatigue may occur in some individuals.

Is ZIFI 200 harmful?

It is safe when used as prescribed but can cause side effects like diarrhea or allergic reactions in some.

What are the benefits of ZIFI?

It treats a variety of bacterial infections effectively.

What is the difference between Zifi O and Zifi 200?

Zifi O contains Cefixime and Ofloxacin (a combination), while Zifi 200 contains only Cefixime.

What is Cefixime 200MG used for?

It treats bacterial infections like respiratory, urinary, and ear infections.

Can ZIFI and Azithromycin be taken together?

Yes, they can be combined for certain infections, but only under medical supervision.