Zerodol SP : Uses, Dosage, Side Effects, and Price

Are you experiencing persistent pain and inflammation that's disrupting your daily life?

Look no further than Zerodol SP Tab, a highly effective pain relief medication that's specifically designed to target and alleviate pain and inflammation.

What is Zerodol SP Tab?

Zerodol SP Tab is a prescription medication that combines the potent pain-relieving properties of Aceclofenac, a nonsteroidal anti-inflammatory drug (NSAID), with the added benefits of Paracetamol, a trusted pain reliever and antipyretic.

This powerful combination makes Zerodol SP Tab an ideal treatment option for a range of painful conditions, including osteoarthritis, rheumatoid arthritis, and musculoskeletal disorders.

Key Benefits of Zerodol SP Tab

Rapid Pain Relief: Zerodol SP Tab works quickly to relieve pain and inflammation, allowing you to get back to your normal activities.

Effective Inflammation Reduction: The Aceclofenac in Zerodol SP Tab helps to reduce inflammation, which can contribute to pain and discomfort.

Convenient Dosage: Zerodol SP Tab is available in a convenient tablet form, making it easy to take as directed by your doctor.

Consult Your Doctor Today

If you're struggling with pain and inflammation, consult your doctor about Zerodol SP Tab.

With its powerful combination of pain-relieving ingredients, Zerodol SP Tab can help you find relief and get back to living your life to the fullest.

Composition of Zerodol SP Tab

Zerodol SP Tab is a prescription medication that contains a combination of three active ingredients:

Aceclofenac (100mg): A nonsteroidal anti-inflammatory drug (NSAID) that helps to relieve pain and reduce inflammation.

Paracetamol (325mg): A pain reliever and antipyretic that helps to relieve pain and reduce fever.

Serratiopeptidase (15mg): A proteolytic enzyme that helps to break down protein-based inflammatory mediators, reducing inflammation and promoting healing.

These three ingredients work together to provide rapid and effective relief from pain and inflammation.

Indications of Zerodol SP Tab

Zerodol SP Tab is a prescription medication that is indicated for the relief of pain and inflammation in various conditions. Here are some of the indications of Zerodol SP Tab in detail:

Musculoskeletal Disorders

Osteoarthritis:

Zerodol SP Tab is indicated for the relief of pain and inflammation associated with osteoarthritis, a degenerative joint disease that causes cartilage loss and joint pain.

Rheumatoid Arthritis:

Zerodol SP Tab is indicated for the relief of pain and inflammation associated with rheumatoid arthritis, an autoimmune disease that causes joint inflammation and pain.

Ankylosing Spondylitis:

Zerodol SP Tab is indicated for the relief of pain and inflammation associated with ankylosing spondylitis, a chronic inflammatory disease that affects the spine and other joints.

Musculoskeletal Pain:

Zerodol SP Tab is indicated for the relief of musculoskeletal pain, including back pain, neck pain, and muscle pain.

Soft Tissue Injuries

Sprains and Strains:

Zerodol SP Tab is indicated for the relief of pain and inflammation associated with sprains and strains, which are common soft tissue injuries.

Tendinitis:

Zerodol SP Tab is indicated for the relief of pain and inflammation associated with tendinitis, a condition characterized by inflammation of the tendons.

Post-Surgical Pain

Post-Operative Pain:

Zerodol SP Tab is indicated for the relief of post-operative pain and inflammation following surgical procedures.

Other Conditions

Dysmenorrhea:

Zerodol SP Tab is indicated for the relief of pain associated with dysmenorrhea, which is characterized by painful menstrual cramps.

Toothache:

Zerodol SP Tab is indicated for the relief of toothache pain.

It's essential to note that Zerodol SP Tab should only be used under the guidance of a healthcare professional and for the indications specified.

Mode of Action of Zerodol SP Tab

Zerodol SP Tab is a combination medication that contains Aceclofenac, Paracetamol, and Serratiopeptidase.

Each of these ingredients works through different mechanisms to provide relief from pain and inflammation.

Aceclofenac

Inhibition of Prostaglandin Synthesis: Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins. Prostaglandins are chemicals that cause pain, inflammation, and fever.

Reduction of Inflammation:

By inhibiting prostaglandin synthesis, Aceclofenac reduces inflammation and swelling, which can contribute to pain and discomfort.

Analgesic Effects:

Aceclofenac also has analgesic properties, which help to relieve pain.

Paracetamol

Inhibition of Prostaglandin Synthesis in the Brain:

Paracetamol works by inhibiting the production of prostaglandins in the brain, which helps to relieve pain and reduce fever.

Blocking the Production of Pain-Causing Chemicals:

Paracetamol also blocks the production of pain-causing chemicals, such as bradykinin, which is involved in the transmission of pain signals.

Analgesic and Antipyretic Effects:

Paracetamol has analgesic and antipyretic effects, which help to relieve pain and reduce fever.

Serratiopeptidase

Proteolytic Activity:

Serratiopeptidase is a proteolytic enzyme that breaks down protein-based inflammatory mediators, such as bradykinin and histamine, which contribute to inflammation and pain.

Anti-Inflammatory Effects:

By breaking down inflammatory mediators, Serratiopeptidase reduces inflammation and swelling, which can contribute to pain and discomfort.

Fibrinolytic Activity:

Serratiopeptidase also has fibrinolytic activity, which helps to break down fibrin clots that can form in response to injury or inflammation.

Overall Mechanism of Action

The combination of Aceclofenac, Paracetamol, and Serratiopeptidase in Zerodol SP Tab works synergistically to provide relief from pain and inflammation. Aceclofenac and Paracetamol work to relieve pain and reduce inflammation, while Serratiopeptidase breaks down inflammatory mediators and promotes healing.

Pharmacokinetics of Zerodol SP

Aceclofenac

Absorption:

Aceclofenac is well absorbed after oral administration, with a bioavailability of approximately 100%.

Distribution:

Aceclofenac is widely distributed throughout the body, with a volume of distribution (Vd) of approximately 25 L.

Metabolism:

Aceclofenac is metabolized in the liver by the enzyme CYP2C9, with a half-life (t1/2) of approximately 4-5 hours.

Excretion:

Aceclofenac is excreted primarily in the urine, with approximately 70-80% of the dose excreted as unchanged drug.

Paracetamol

Absorption:

Paracetamol is rapidly absorbed after oral administration, with a bioavailability of approximately 100%.

Distribution:

Paracetamol is widely distributed throughout the body, with a Vd of approximately 0.9 L/kg.

Metabolism:

Paracetamol is metabolized in the liver by the enzymes CYP2E1 and CYP3A4, with a t1/2 of approximately 2-3 hours.

Excretion:

Paracetamol is excreted primarily in the urine, with approximately 90-100% of the dose excreted as unchanged drug.

Serratiopeptidase

Absorption:

Serratiopeptidase is absorbed after oral administration, but its bioavailability is relatively low due to degradation by stomach acid.

Distribution:

Serratiopeptidase is distributed throughout the body, with a Vd of approximately 0.2 L/kg.

Metabolism:

Serratiopeptidase is metabolized by proteolytic enzymes in the gut and liver, with a t1/2 of approximately 1-2 hours.

Excretion:

Serratiopeptidase is excreted primarily in the feces, with approximately 50-60% of the dose excreted as unchanged drug.

Pharmacokinetic Interactions

Food:

Food can affect the absorption of Aceclofenac and Paracetamol, but not significantly.

Other Medications:

Concomitant use of Zerodol SP Tab with other medications, such as anticoagulants, anti-diabetic agents, and certain antidepressants, may increase the risk of adverse effects or interactions.

Dosage of Zerodol SP Tab

Adult Dosage

Recommended Dosage:

The recommended dosage of Zerodol SP Tab for adults is 1 tablet every 8-12 hours, not to exceed 3 tablets in 24 hours.

Maximum Dosage:

The maximum dosage of Zerodol SP Tab for adults is 3 tablets in 24 hours.

Pediatric Dosage

Children under 12 years:

Zerodol SP Tab is not recommended for children under 12 years old.

Children 12-18 years:

The recommended dosage of Zerodol SP Tab for children 12-18 years old is 1 tablet every 8-12 hours, not to exceed 2 tablets in 24 hours.

Geriatric Dosage

Elderly patients: The recommended dosage of Zerodol SP Tab for elderly patients is 1 tablet every 8-12 hours, not to exceed 2 tablets in 24 hours.

Dosage Adjustments

Renal impairment:

Patients with renal impairment may require dosage adjustments. The recommended dosage is 1 tablet every 12 hours.

Hepatic impairment:

Patients with hepatic impairment may require dosage adjustments. The recommended dosage is 1 tablet every 12 hours.

Duration of Treatment

Acute pain: The duration of treatment for acute pain is typically 3-5 days.

Chronic pain: The duration of treatment for chronic pain is typically longer, and may require ongoing treatment.

Overdose

Symptoms: Symptoms of overdose may include nausea, vomiting, abdominal pain, and dizziness.

Treatment: Treatment of overdose involves supportive care, such as hydration and monitoring of vital signs.

Use of Zerodol SP in Toothache Pain

Zerodol SP Tab can be used to relieve toothache pain, but it's essential to follow the guidelines and precautions outlined below:

How Zerodol SP Works for Toothache Pain

Pain Relief:

The Paracetamol in Zerodol SP Tab helps to relieve toothache pain by blocking the production of prostaglandins, which are chemicals that cause pain.

Anti-Inflammatory Effects:

The Aceclofenac in Zerodol SP Tab helps to reduce inflammation and swelling, which can contribute to toothache pain.

When to Use Zerodol SP for Toothache Pain

Mild to Moderate Pain:

Zerodol SP Tab can be used to relieve mild to moderate toothache pain.

Temporary Relief:

Zerodol SP Tab can provide temporary relief from toothache pain until you can see a dentist.

Dosage and Administration in Toothache

Adults: The recommended dosage is 1 tablet every 8-12 hours, not to exceed 3 tablets in 24 hours.

Children: Zerodol SP Tab is not recommended for children under 12 years old.

Precautions and Contraindications

Dental Consultation:

It's essential to consult a dentist to determine the cause of the toothache and receive proper treatment.

Not a Substitute for Dental Care:

Zerodol SP Tab is not a substitute for dental care. You should still see a dentist to treat the underlying cause of the toothache.

Allergic Reactions:

If you're allergic to any of the ingredients in Zerodol SP Tab, you should not take it.

Stomach Problems:

If you have stomach problems, such as ulcers or bleeding, you should use Zerodol SP Tab with caution.

Remember, Zerodol SP Tab is only for temporary relief of toothache pain. You should always consult a dentist to determine the cause of the toothache and receive proper treatment.

Side Effects of Zerodol SP Tab

Common Side Effects

Gastrointestinal Side Effects:

Nausea

Vomiting

Abdominal pain

Diarrhea

Constipation

Central Nervous System Side Effects:

Headache

Dizziness

Drowsiness

Fatigue

Dermatological Side Effects:

Skin rash

Pruritus

Urticaria

Cardiovascular Side Effects:

Hypertension

Tachycardia

Palpitations

Serious Side Effects

Gastrointestinal Side Effects:

Ulceration

Bleeding

Perforation

Hepatic Side Effects:

Elevated liver enzymes

Hepatitis

Jaundice

Renal Side Effects:

Acute kidney injury

Chronic kidney disease

Hematological Side Effects:

Anemia

Leukopenia

Thrombocytopenia

Allergic Reactions:

Anaphylaxis

Angioedema

Stevens-Johnson syndrome

Rare but Serious Side Effects

Cardiovascular Side Effects:

Myocardial infarction

Stroke

Neurological Side Effects:

Seizures

Aseptic meningitis

Psychiatric Side Effects:

Depression

Anxiety

Insomnia

Precautions to Minimize Side Effects

Gastrointestinal Protection: Use of proton pump inhibitors (PPIs) or histamine-2 (H2) blockers to reduce the risk of gastrointestinal side effects.

Monitoring of Liver and Kidney Function: Regular monitoring of liver and kidney function to detect any abnormalities.

Monitoring of Blood Pressure: Regular monitoring of blood pressure to detect any changes.

Avoidance of Concomitant Medications: Avoidance of concomitant medications that may increase the risk of side effects.

Contraindications of Zerodol SP

Absolute Contraindications

Hypersensitivity:

Known hypersensitivity to Aceclofenac, Paracetamol, or Serratiopeptidase.

Active Gastrointestinal Ulceration: Active gastrointestinal ulceration or bleeding.

Severe Liver Impairment: Severe liver impairment or liver failure.

Severe Kidney Impairment: Severe kidney impairment or kidney failure.

Heart Failure: Heart failure or severe cardiovascular disease.

Relative Contraindications

Mild to Moderate Liver Impairment: Mild to moderate liver impairment requires dosage adjustment and close monitoring.

Mild to Moderate Kidney Impairment: Mild to moderate kidney impairment requires dosage adjustment and close monitoring.

Gastrointestinal Disorders: Gastrointestinal disorders, such as gastritis, duodenitis, or inflammatory bowel disease, require caution and close monitoring.

Asthma: Asthma or a history of asthma requires caution and close monitoring.

Pregnancy and Breastfeeding: Pregnancy and breastfeeding require caution and close monitoring.

Special Precautions

Elderly Patients: Elderly patients require caution and close monitoring due to increased risk of adverse effects.

Pediatric Patients: Pediatric patients under 12 years old require caution and close monitoring due to limited data on safety and efficacy.

Concomitant Medications: Concomitant medications, such as anticoagulants, anti-diabetic agents, and certain antidepressants, require caution and close monitoring due to increased risk of adverse effects.

Drug Interactions of Zerodol SP

Zerodol-SP is a combination medication typically used for pain and inflammation. It contains Aceclofenac (a non-steroidal anti-inflammatory drug or NSAID), Paracetamol (acetaminophen), and Serratiopeptidase (an enzyme).

Below are the potential drug interactions associated with its components:

1. Aceclofenac

Anticoagulants (e.g., Warfarin):

Increased risk of bleeding due to enhanced anticoagulant effects.

Other NSAIDs or Aspirin:

Increased risk of gastrointestinal side effects such as ulcers or bleeding.

Corticosteroids:

Increased risk of gastrointestinal ulceration or bleeding.

Diuretics and Antihypertensive Drugs: May reduce the effectiveness of these medications by inhibiting prostaglandin synthesis.

Lithium or Methotrexate: May increase the plasma concentration of these drugs, potentially causing toxicity.

Cyclosporine:

Increased risk of nephrotoxicity.

Quinolone Antibiotics:

May increase the risk of seizures.

2. Paracetamol

Alcohol: Increased risk of liver toxicity.

Rifampicin, Carbamazepine, Phenytoin, or Barbiturates:

Increased risk of hepatotoxicity due to enhanced metabolism of paracetamol.

Chloramphenicol:

May increase the plasma concentration of chloramphenicol, leading to toxicity.

Warfarin or Other Anticoagulants: Prolonged use of paracetamol may increase the risk of bleeding.

3. Serratiopeptidase

Anticoagulants (e.g., Warfarin, Heparin): May potentiate the effects, increasing the risk of bleeding.

Antiplatelet Drugs (e.g., Aspirin, Clopidogrel): Increased risk of bleeding.

General Notes:

Avoid combining with medications that have similar effects or increase the risk of toxicity.

Consult a healthcare provider before combining Zerodol-SP with other medications to avoid potential adverse effects.

Safety Advice for Zerodol-SP

Zerodol-SP is a combination medication used for pain relief and reducing inflammation. To ensure safe and effective use, please follow these guidelines:

1. Usage Guidelines

Take Zerodol-SP exactly as prescribed by your doctor.

It is typically taken after meals to minimize the risk of stomach upset or irritation.

Avoid self-medication or exceeding the recommended dose, as it may lead to serious side effects.

2. Avoid in Specific Conditions

Stomach Issues: Avoid if you have a history of ulcers, gastritis, or gastrointestinal bleeding.

Kidney or Liver Problems: Use cautiously and only under medical supervision if you have impaired kidney or liver function.

Heart Problems: Not recommended for patients with severe heart conditions, as it may increase blood pressure or cardiovascular risk.

3. Drug Interactions

Inform your doctor about all other medications, supplements, or herbal remedies you are taking to prevent harmful interactions.

Avoid combining with other NSAIDs (e.g., ibuprofen) or high doses of paracetamol.

4. Pregnancy and Breastfeeding

Not recommended during pregnancy, especially in the third trimester, as it may harm the fetus.

Consult your doctor if you are breastfeeding, as it may pass into breast milk.

5. Alcohol and Lifestyle

Avoid alcohol consumption while taking Zerodol-SP, as it may increase the risk of liver damage and stomach irritation.

Maintain a healthy lifestyle, including a balanced diet and adequate hydration, to support your body during treatment.

6. Side Effects to Watch For

Common side effects include nausea, stomach pain, and indigestion. If these persist, contact your doctor.

Stop the medication and seek immediate medical attention if you experience severe allergic reactions, vomiting blood, black stools, or signs of liver damage (yellowing of eyes/skin).

7. Special Precautions

Do not drive or operate heavy machinery if the medication makes you feel dizzy or drowsy.

Regular monitoring of liver and kidney function may be required if used for an extended period.

When to Seek Help

If pain or inflammation does not improve after a few days, or if you experience unusual symptoms, consult your doctor promptly.

Always follow your doctor’s advice and consult them for any concerns regarding the use of Zerodol-SP. Proper adherence to these safety measures will help you maximize its benefits while minimizing risks.

Price of Zerodol SP

Zerodol SP is available in Pack of 10 tablets in strip and MRP is 139.00 per Strip

Frequently Asked Questions (FAQ) about Zerodol SP

What is Zerodol-SP used for?

Zerodol-SP is a combination medication used to treat:

Pain and Inflammation: Commonly prescribed for conditions like arthritis, back pain, and musculoskeletal disorders.

Post-Surgical Pain: Helps reduce pain and swelling after surgical procedures.

Sports Injuries: Useful in managing swelling and pain due to sprains or strains.

Is Zerodol a strong painkiller?

Zerodol and its variants (like Zerodol-SP) are considered moderate to strong painkillers, depending on the condition.

The combination of Aceclofenac (NSAID) and Paracetamol provides effective pain relief and anti-inflammatory effects.

Serratiopeptidase, an enzyme, helps in reducing swelling and promoting faster healing.

While effective for moderate to severe pain, it is not as strong as opioid-based painkillers and is generally considered safer for long-term use when taken as prescribed.

What is the difference between Zerodol-MR and Zerodol-SP?

The main difference between Zerodol-MR and Zerodol-SP lies in their composition and uses.

Composition

Zerodol-MR: Contains a combination of Aceclofenac (100mg) and Tizanidine (2mg) ¹.

Zerodol-SP: Contains a combination of Aceclofenac (100mg), Paracetamol (325mg), and Serratiopeptidase (10mg) ¹.

Zerodol-MR: Primarily used to relieve pain and inflammation associated with conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and muscle spasms ¹.

Zerodol-SP: Used to treat pain and inflammation caused by conditions like arthritis, toothache, and musculoskeletal disorders ².

Key Differences

Tizanidine vs. Paracetamol and Serratiopeptidase: Zerodol-MR contains Tizanidine, a muscle relaxant, whereas Zerodol-SP contains Paracetamol, a pain reliever, and Serratiopeptidase, an anti-inflammatory enzyme .

Pain Relief and Muscle Relaxation: Zerodol-MR is geared more towards relieving muscle spasms and pain, while Zerodol-SP is focused on providing overall pain relief and reducing inflammation .

Which is more powerful: Zerodol-P or Zerodol-SP?

Zerodol-P contains Aceclofenac and Paracetamol, providing pain relief and anti-inflammatory effects.

Zerodol-SP adds Serratiopeptidase, which enhances anti-inflammatory effects by reducing swelling and promoting tissue healing.

Zerodol-SP is considered more effective for conditions involving significant inflammation or swelling, while Zerodol-P is better for general pain relief.

Is Zerodol-SP safe for kidneys?

Zerodol-SP can strain the kidneys, especially in people with pre-existing kidney issues or prolonged use.

Precautions:

Avoid if you have kidney impairment.

Stay hydrated while on this medication.

Regular monitoring is advised for patients with mild kidney conditions or those taking it long-term.

Consult a doctor for a personalized evaluation.

What are the side effects of Aceclofenac?

Common side effects include:

Gastrointestinal: Nausea, vomiting, abdominal pain, indigestion, and diarrhea.

Liver-related: Elevated liver enzymes or rare liver toxicity with prolonged use.

Kidneys: May impair kidney function, especially in those with pre-existing conditions.

Allergic reactions: Skin rashes, itching, or breathing difficulties.

Cardiovascular: Increased risk of hypertension and cardiovascular issues with prolonged use.

Who should not take Zerodol?

Zerodol or its variants should not be used by:

Allergic individuals: Those allergic to NSAIDs, paracetamol, or serratiopeptidase.

Pregnant or breastfeeding women: Particularly during the third trimester.

Patients with severe conditions:

Kidney or liver impairment.

Severe heart failure.

History of peptic ulcers or GI bleeding.

Children: Unless specifically prescribed.

Individuals on blood thinners or anticoagulants: Due to the risk of bleeding.

Is Zerodol a muscle relaxant?

No, Zerodol is not a muscle relaxant.

It is primarily an NSAID for pain relief and inflammation.

If muscle relaxation is needed, Zerodol-MR (which includes Tizanidine, a muscle relaxant) may be prescribed.

Here’s a list of additional FAQs about Zerodol-SP:

How long can Zerodol-SP be taken?

Zerodol-SP is usually prescribed for short-term use, typically a few days to a couple of weeks, depending on the condition.

Prolonged use can increase the risk of side effects such as kidney or liver damage. Always follow your doctor’s guidance.

Can Zerodol-SP be taken on an empty stomach?

It is not recommended to take Zerodol-SP on an empty stomach, as it may cause stomach irritation or ulcers.

Take it after meals to reduce the risk of gastrointestinal side effects.

Is Zerodol-SP an antibiotic?

No, Zerodol-SP is not an antibiotic. It is a combination of an NSAID (Aceclofenac), an analgesic/antipyretic (Paracetamol), and an enzyme (Serratiopeptidase) used to treat pain, inflammation, and swelling.

Can Zerodol-SP cause drowsiness?

Zerodol-SP does not typically cause drowsiness. However, individual responses may vary, and some people might experience mild dizziness. Avoid driving or operating machinery if affected.

Is Zerodol-SP safe for diabetics?

Zerodol-SP can be used in diabetic patients, but caution is required as it may occasionally affect kidney function or interfere with other diabetes medications.

Regular monitoring of blood sugar and kidney function is advised.

Can Zerodol-SP be used for toothache?

Yes, Zerodol-SP is commonly prescribed for toothache and dental procedures as it helps reduce pain, swelling, and inflammation.

What happens if I miss a dose of Zerodol-SP?

If you miss a dose, take it as soon as you remember.

If it’s close to the time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose.

Can Zerodol-SP be taken with alcohol?

No, alcohol consumption should be avoided while taking Zerodol-SP as it increases the risk of liver damage and gastrointestinal side effects.

Does Zerodol-SP help with fever?

Yes, the paracetamol in Zerodol-SP can help reduce fever. However, it is primarily prescribed for pain and inflammation rather than as a standalone fever medication.

Can Zerodol-SP be used for menstrual pain?

Zerodol-SP may be prescribed for menstrual pain (dysmenorrhea) if inflammation or severe pain is present. However, specific medications like mefenamic acid are often preferred.

Does Zerodol-SP have a risk of addiction?

No, Zerodol-SP does not contain addictive substances and has no potential for dependency.

Can Zerodol-SP cause weight gain?

Zerodol-SP is not known to cause weight gain. However, prolonged use of NSAIDs can lead to fluid retention, which may temporarily increase weight.

What should I do in case of an overdose?

Symptoms of overdose may include nausea, vomiting, abdominal pain, dizziness, or severe liver and kidney damage.

Seek immediate medical attention in case of an overdose.

Is Zerodol-SP suitable for elderly patients?

Elderly patients may use Zerodol-SP, but with caution. They are more prone to side effects like gastrointestinal issues and kidney problems. Lower doses or alternative medications might be recommended.

Can Zerodol-SP be stopped abruptly?

Zerodol-SP can generally be stopped once the pain or inflammation subsides. However, for chronic conditions, consult your doctor before discontinuing.