Crocin 650 : Uses, Composition ,Dosage ,Side Effects

Are you experiencing mild to moderate pain due to headaches, toothaches, or muscle aches?

Look no further than Crocin 650 mg tab, a trusted and effective pain reliever. Containing 650mg of Paracetamol (Acetaminophen), Crocin 650 mg tab provides quick and sustained relief from pain and fever, helping you get back to your daily routine.

Key Benefits:

Relieves mild to moderate pain

Reduces fever

Fast-acting and long-lasting relief

Suitable for various types of pain, including headaches, toothaches, and muscle aches.

Composition of Crocin 650

Each Crocin 650 tablet contains:

Paracetamol (Acetaminophen) - 650mg

How Crocin 650 Works ?

What Happens When We Feel Pain?

When we get hurt or injured, our body sends signals to the brain, which interprets these signals as pain. These signals are like messages sent through a messenger.

How Does Crocin 650 Stop Pain?

Crocin 650 contains Paracetamol, which works by blocking the production of certain chemicals in the body called prostaglandins. These chemicals are like the messengers that carry pain signals to the brain.

When Paracetamol blocks prostaglandins, it essentially stops the pain messages from being sent to the brain. As a result, we don't feel the pain anymore.

How Does Crocin 650 Reduce Fever?

When we have a fever, our body temperature rises above normal. This is usually a response to an infection or illness.

Crocin 650 works by acting on the part of the brain that regulates body temperature, called the hypothalamus.

Paracetamol helps to reset the body's thermostat, bringing the temperature back down to normal.

Simple Analogy to get relief

Think of pain and fever like a fire alarm. When the alarm goes off, it's like the pain or fever signal being sent to the brain.

Crocin 650 is like the fire alarm's off switch. It turns off the alarm, stopping the pain or fever signal from reaching the brain.

This helps us feel better and get back to our daily routine.

Dosage of Crocin 650

Crocin 650 is a brand of paracetamol (acetaminophen) used for pain relief and to reduce fever. The dosage depends on age, weight, and the condition being treated. Below are general guidelines:

For Adults:

Recommended Dose: 1 tablet (650 mg) every 4–6 hours as needed.

Maximum Dose: Do not exceed 4,000 mg (6 tablets) in 24 hours.

Usage: Take with water after meals to reduce stomach upset.

For Children (12–18 years):

Recommended Dose: 1 tablet (650 mg) every 4–6 hours as needed.

Maximum Dose: Do not exceed 4,000 mg (6 tablets) in 24 hours.

For Children (below 12 years):

The dosage is usually calculated based on weight: 10–15 mg/kg body weight every 4–6 hours as needed.

Crocin 650 is generally not recommended for children below 12 years. Instead, pediatric formulations of paracetamol should be used. Consult a doctor for precise dosing.

Precautions:

1. Do not exceed the recommended dose as it may cause liver damage.

2. Avoid using Crocin 650 if you have liver or kidney disease, or if advised by your doctor.

3. Do not take with alcohol as it increases the risk of liver damage.

4. If symptoms persist for more than 3 days (fever) or 5 days (pain), consult a doctor

For personalized dosing, always consult a healthcare professional

Side effects of Crocin 650

Crocin 650 (paracetamol/acetaminophen) is generally safe when taken at recommended doses, but it can cause side effects in some cases. These side effects can range from mild to severe and are often dose-dependent. Below is a detailed breakdown:

Common Side Effects (Usually Mild):

Nausea

Vomiting

Stomach pain or discomfort

Loss of appetite

Less Common Side Effects:

Skin rash

Itching or redness

Dizziness

Fatigue

Rare but Serious Side Effects:

These usually occur with an overdose, long-term use, or in individuals with pre-existing conditions.

Liver damage: Symptoms include jaundice (yellowing of the skin/eyes), dark urine, or pale stools.

Kidney damage: Decreased urine output or swelling in the legs/ankles.

Severe allergic reactions (rare):

Symptoms: Difficulty breathing, swelling of the face, throat, or tongue (angioedema), and hives.

Blood disorders: Reduced blood cell counts, leading to symptoms like fatigue, easy bruising, or frequent infections.

Skin reactions: Rare but severe skin conditions like Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

Overdose Symptoms:

An overdose of Crocin 650 can cause serious complications, particularly liver failure. Symptoms of overdose include:

Extreme nausea and vomiting

Loss of appetite

Confusion or drowsiness

Severe abdominal pain

Sweating or clamminess

Yellowing of the skin/eyes (jaundice)

Dark urine

Important: If an overdose is suspected, seek medical help immediately. Activated charcoal or acetylcysteine may be used as an antidote in a hospital setting.

Precautions to Minimize Side Effects:

1. Avoid Alcohol: Combining alcohol with paracetamol increases the risk of liver damage.

2. Follow Dosage Guidelines: Do not exceed the recommended dose (max 4,000 mg/day for adults).

3. Pre-existing Conditions: Consult a doctor if you have liver or kidney disease before taking Crocin 650.

4. Medication Interactions: Avoid combining Crocin 650 with other medications containing paracetamol to prevent overdose.

If you experience any severe or unusual side effects, stop the medication and consult a healthcare provider immediately

Pharmacokinetics of Crocin 650

Crocin 650, containing Paracetamol (Acetaminophen) 650mg, exhibits the following pharmacokinetic properties:

Absorption:

Route of Administration: Oral

Absorption Rate: Rapid

Peak Plasma Concentration (Tmax): 30 minutes to 1 hour

Bioavailability: Approximately 80-100%

Distribution:

Volume of Distribution (Vd): 0.9-1.3 L/kg

Protein Binding: Less than 10% bound to plasma proteins

Metabolism:

Metabolic Pathway: Hepatic, primarily via glucuronidation and sulfation

Major Metabolites: Paracetamol glucuronide, paracetamol sulfate, and N-acetyl-p-benzoquinone imine (NAPQI)

Excretion:

Renal Excretion: Primarily through kidneys

Elimination Half-Life (t1/2): 2-3 hours

Total Clearance: 5-7 mL/min/kg

Special Populations:

Pediatric Patients: Pharmacokinetics similar to adults

Geriatric Patients: May have reduced clearance and increased t1/2

Hepatic Impairment: May have reduced clearance and increased t1/2

Renal Impairment: May have reduced clearance and increased t1/2

Please note that these pharmacokinetic parameters are approximate and may vary depending on individual factors, such as age, weight, and liver or kidney function.

Contraindications of Crocin 650

Crocin 650 is contraindicated in the following conditions:

Absolute Contraindications:

Known hypersensitivity to Paracetamol (Acetaminophen): Patients who have previously experienced an allergic reaction to Paracetamol should not take Crocin 650.

Severe liver impairment: Patients with severe liver disease or liver failure should not take Crocin 650.

Severe kidney impairment: Patients with severe kidney disease or kidney failure should not take Crocin 650.

Relative Contraindications:

Mild to moderate liver impairment: Patients with mild to moderate liver disease should use Crocin 650 with caution and under medical supervision.

Mild to moderate kidney impairment: Patients with mild to moderate kidney disease should use Crocin 650 with caution and under medical supervision.

Chronic alcoholism: Patients who consume excessive alcohol should use Crocin 650 with caution, as it may increase the risk of liver damage.

Malnutrition: Patients who are malnourished or have a low body mass index (BMI) should use Crocin 650 with caution.

Pregnancy and lactation: Crocin 650 should be used with caution during pregnancy and lactation, and only under medical supervision.

Other Contraindications:

Concomitant use with other Paracetamol-containing products: Patients should not take Crocin 650 with other products that contain Paracetamol, as it may increase the risk of overdose.

Concomitant use with warfarin: Patients taking warfarin should use Crocin 650 with caution, as it may increase the risk of bleeding.

Drug Interactions of Crocin 650

Crocin 650, containing Paracetamol (Acetaminophen) 650mg, may interact with the following medications:

Major Interactions:

Warfarin: Concomitant use of Crocin 650 and warfarin may increase the risk of bleeding.

Anticonvulsants (e.g., phenytoin, carbamazepine): Long-term use of Crocin 650 with anticonvulsants may increase the risk of liver damage.

Rifampicin: Concomitant use of Crocin 650 and rifampicin may decrease the effectiveness of Crocin 650.

Cholestyramine: Concomitant use of Crocin 650 and cholestyramine may decrease the absorption of Crocin 650.

Moderate Interactions:

Anticoagulants (e.g., aspirin, heparin): Concomitant use of Crocin 650 and anticoagulants may increase the risk of bleeding.

Oral hypoglycemic agents (e.g., metformin): Concomitant use of Crocin 650 and oral hypoglycemic agents may increase the risk of hypoglycemia.

Blood thinners (e.g., clopidogrel): Concomitant use of Crocin 650 and blood thinners may increase the risk of bleeding.

Minor Interactions:

Antacids (e.g., aluminum hydroxide): Concomitant use of Crocin 650 and antacids may decrease the absorption of Crocin 650.

Histamine H2-receptor antagonists (e.g., ranitidine): Concomitant use of Crocin 650 and histamine H2-receptor antagonists may decrease the absorption of Crocin 650.

Food Interactions:

Caffeine: Excessive caffeine consumption may increase the risk of liver damage when taken with Crocin 650.

Alcohol: Excessive alcohol consumption may increase the risk of liver damage when taken with Crocin 650.

Frequently asked questions about Crocin 650 (FAQ)

1. What is Crocin 650 used for?

Crocin 650 is used for relieving mild to moderate pain and reducing fever. It is commonly used to treat headaches, toothaches, muscle aches, backaches, and menstrual cramps.

2. Is Crocin a strong painkiller?

Crocin 650 contains Paracetamol (Acetaminophen) 650mg, which is a mild to moderate pain reliever. It is not considered a strong painkiller, but it is effective for relieving everyday aches and pains.

3. Can Crocin be taken on an empty stomach?

It is recommended to take Crocin 650 with food or milk to avoid stomach upset. Taking it on an empty stomach may increase the risk of stomach irritation and other gastrointestinal side effects.

4. Can I take 2 Crocin 650 in a day?

The recommended dosage of Crocin 650 is 1 tablet every 4-6 hours as needed, not to exceed 4 tablets in 24 hours. Taking more than the recommended dose can increase the risk of liver damage and other side effects.

5. Does Crocin make you sleepy?

Crocin 650 is not typically known to cause drowsiness or sleepiness. However, some people may experience dizziness or drowsiness after taking Crocin 650, especially if they are sensitive to the medication or take it with other sedating medications.

6. Does Crocin 650 affect the kidneys?

Crocin 650 is primarily metabolized by the liver and excreted by the kidneys. While it is generally safe for people with normal kidney function, it may not be suitable for people with severe kidney impairment or kidney failure.

7. Which is better, Crocin or Crocin?

Both Crocin 650 and Crocin are popular pain relievers containing Paracetamol (Acetaminophen). The choice between the two depends on individual preferences and needs. Some people may prefer Crocin 650 for its faster onset of action, while others may prefer Crocin for its longer duration of action.

8. Is Crocin an antibiotic?

No, Crocin 650 is not an antibiotic. It is a pain reliever and antipyretic (fever reducer) that contains Paracetamol (Acetaminophen).

9. Is Crocin 650 banned in India in 2018?

No, Crocin 650 was not banned in India in 2018. In fact, it remains one of the most widely used and prescribed pain relievers in India.

10. What is the difference between paracetamol and Crocin 650?

Paracetamol and Crocin 650 are essentially the same thing. Paracetamol is the active ingredient in Crocin 650, which is a brand name for the medication. Crocin 650 contains 650mg of Paracetamol per tablet.

11. Which is better Combiflam or Crocin 650?

Combiflam and Crocin 650 are both pain relievers, but they contain different active ingredients. Combiflam contains a combination of ibuprofen and paracetamol, while Crocin 650 contains only paracetamol. The choice between the two depends on individual needs and preferences.

12. Does Crocin have aspirin?

No, Crocin 650 does not contain aspirin. It contains only paracetamol (acetaminophen) 650mg.

13. What is the age limit for paracetamol 650?

Paracetamol 650mg is generally recommended for adults and children above 12 years of age. However, the dosage and age limit may vary depending on individual needs and medical conditions.

14. Can a sugar patient take Crocin ?

Yes, sugar patients (diabetics) can take Crocin 650, but they should consult their doctor before taking it. Crocin 650 does not contain sugar, but it may affect blood sugar levels.

15. Can I take Crocin 650 for cold and cough?

Crocin 650 can help relieve headaches, fever, and body aches associated with cold and cough. However, it does not treat the underlying cause of the cold and cough.

16. What happens if we use Crocin 650 without fever?

Taking Crocin 650 without fever will not cause harm, but it may not provide any benefits either. Crocin 650 is primarily used to reduce fever and relieve pain.

17. Can I take cetirizine and Crocin 650 together?

Yes, you can take cetirizine (an antihistamine) and Crocin 650 together, but you should consult your doctor before taking them. There are no known interactions between cetirizine and paracetamol.

18. Is Crocin 650 safe?

Crocin 650 is generally considered safe when taken as directed. However, it may cause side effects such as nausea, vomiting, and stomach upset in some individuals.

19. What happens if we take Crocin 650 without food?

Taking Crocin 650 without food may increase the risk of stomach upset, nausea, and vomiting.

20. Does Crocin 650 affect the kidneys?

Crocin 650 is primarily metabolized by the liver and excreted by the kidneys. While it is generally safe for people with normal kidney function, it may not be suitable for people with severe kidney impairment or kidney failure.

21. Can we take azithromycin with Crocin ?

Yes, you can take azithromycin (an antibiotic) with Crocin 650, but you should consult your doctor before taking them. There are no known interactions between azithromycin and paracetamol.

23. Can I take Crocin 650 after eating chicken?

Yes, you can take Crocin 650 after eating chicken or any other food. However, it is recommended to take Crocin 650 with food to avoid stomach upset.

24. How much time does Crocin 650 take to reduce fever?

Crocin 650 typically starts to reduce fever within 30 minutes to 1 hour after ingestion. The maximum effect is usually seen within 2-3 hours.

25. Can I take Crocin 650 during pregnancy?

It is recommended to consult a doctor before taking Crocin 650 during pregnancy. While paracetamol is generally considered safe during pregnancy, high doses or prolonged use may increase the risk of liver damage.

26. Can I take Crocin 650 while breastfeeding?

It is recommended to consult a doctor before taking Crocin 650 while breastfeeding. Paracetamol is excreted in breast milk, but the amount is generally considered safe for infants.

27. Can I give Crocin 650 to my child?

Crocin 650 is not recommended for children below 12 years of age. For children above 12 years of age, the recommended dose is 1 tablet every 4-6 hours as needed, not to exceed 4 tablets in 24 hours.

28. Can I take Crocin 650 with other pain relievers?

It is not recommended to take Crocin 650 with other pain relievers, such as ibuprofen or aspirin, without consulting a doctor. Combining pain relievers may increase the risk of side effects.

29. Can I take Crocin 650 for menstrual cramps?

Yes, Crocin 650 can be taken to relieve menstrual cramps. However, it is recommended to consult a doctor if the cramps are severe or persistent.

30. Can I take Crocin 650 for headaches?

Yes, Crocin 650 can be taken to relieve headaches. However, it is recommended to consult a doctor if the headaches are frequent, severe, or persistent.

31. Can I take Crocin 650 with antacids?

Yes, Crocin 650 can be taken with antacids. However, it is recommended to take the antacid at least 2 hours after taking Crocin 650.

32. Can I crush or chew Crocin 650 tablets?

No, it is not recommended to crush or chew Crocin 650 tablets. This may affect the release of the active ingredient and increase the risk of side effects.

33. Can I take Crocin 650 with herbal supplements?

It is recommended to consult a doctor before taking Crocin 650 with herbal supplements. Some herbal supplements may interact with paracetamol and increase the risk of side effects.

34. What should I do if I miss a dose of Crocin 650?

If you miss a dose of Crocin 650, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

35.List some substitutes of Crocin 650 with company name

Here are some substitutes for Crocin 650:

Dolo 650 MG Tablet: Micro labs

Calpol 650 MG Tablet: Glaxosmithkline Pharmaceuticals Ltd,

Doliprane 650 MG Tablet: Abbott Healthcare Pvt. Ltd

Paracip 650 MG Tablet: Cipla Ltd

Lanol ER 650mg Tablet: Hetero Healthcare